neuron floor.jpg

Publications

Dr. Trujillo has been publishing research for over 30 years. Here are some of his contributions to the fields of neurovirology and photodynamic therapy

Long Term Effectiveness of Photodynamic Therapy for CIN Treatment.  Inada NM, Buzzá HH, Leite MFM, Kurachi C, Trujillo JR, de Castro CA, Carbinatto FM, Lombardi W, Bagnato VS. Pharmaceuticals (Basel). 2019 Jul 12;12(3):107. doi: 10.3390/ph12030107.

Photodynamic therapy: Progress toward a scientific and clinical network in Latin America.  Buzzá HH, Silva APD, Vollet Filho JD, Trujillo JR, et al.. Photodiagnosis Photodyn Ther. 2016;13:261-266. doi:10.1016/j.pdpdt.2015.08.004

Gliomas and brain lymphomas in HIV-1/AIDS patients: reflections from a 20-year follow up in Mexico and Brazil Filiberto Cedeno-Laurent, J. Roberto Trujillo. Microbiology Research June 2011; volume 3:e11 DOI:10.4081/mr.2011.e11

PDT.jpg

Photodynamic therapy Light stimulates a photosensitizer to release toxic singlet oxygen which destroys targeted cancer cells . See paper

mannose receptor.jpg

Model of noninfectious HIV-1 entry into antigen presenting cells. The mannose-rich carbohydrates of gp120 initiate a noninfectious phagocytic pathway. This pathway links microbial antigen recognition by mannose receptors with presentation by CD1b, for the induction of cell-mediated immunity.  See paper

Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era.  Cedeno-Laurent F, Penalva de Oliveira AC, Vidal JE, Trujillo JR. Patholog Res Int. 2011 Feb 22;2011:562427. doi: 10.4061/2011/562427.

 

New insights into HIV-1-primary skin disorders.  Cedeno-Laurent F, Gómez-Flores M, Mendez N, Ancer-Rodríguez J, Bryant JL, Gaspari AA, Trujillo JR. J Int AIDS Soc. 2011 Jan 24;14:5. doi: 10.1186/1758-2652-14-5.

 

Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1. Cedeno-Laurent F, Bryant J, Fishelevich R, Trujillo JR, et al. J Dermatol Sci. 2009;53(2):112-119. doi:10.1016/j.jdermsci.2008.08.015

Aids-related progressive multifocal leukoencephalopathy: a retrospective study in a referral center in São Paulo, Brazil. Vidal JE, Penalva de Oliveira AC, Fink MC, Pannuti CS, Trujillo JR. Rev Inst Med Trop Sao Paulo. 2008;50(4):209-212. doi:10.1590/s0036-46652008000400004

Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor Trujillo JR, Rogers R, Molina RM, et al.. Proc Natl Acad Sci U S A. 2007;104(12):5097-5102. doi:10.1073/pnas.0611263104

BK virus associated meningoencephalitis in an AIDS patient treated with HAART. Vidal JE, Fink MC, Cedeno-Laurent F, Trujillo JR, et al. AIDS Res Ther. 2007;4:13. Published 2007 Jun 8. doi:10.1186/1742-6405-4-13

Neurocysticercosis and HIV-1, 25 years of a co-infection follow-up. Cedeno-Laurent F, Ramírez-Rodríguez C, García-Ramos G, et al. Rev Mex Neuroci. 2007;8(3):274-275.
 

International NeuroAIDS: prospects of HIV-1 associated neurological complications.  Trujillo JR, Jaramillo-Rangel G, Ortega-Martinez M, Penalva de Oliveira AC, Vidal JE, Bryant J, Gallo RC. Cell Res. 2005 Nov-Dec;15(11-12):962-9. doi: 10.1038/sj.cr.7290374.

 

The molecular epidemiology of HIV type 1 of men in Mexico. Rivera-Morales LG, Novitsky VA, Trujillo JR, et al. AIDS Res Hum Retroviruses. 2001;17(1):87-92. doi:10.1089/088922201750056825

T-tropic sequence of the V3 loop is critical for HIV-1 infection of CXCR4-positive colonic HT-29 epithelial cells. Trujillo JR, Goletiani NV, Bosch I, et al. J Acquir Immune Defic Syndr. 2000;25(1):1-10. doi:10.1097/00042560-200009010-00001

Neurocysticercosis & HIV .jpg

Neurocysticercosis and HIV protection Co-infection of the central nervous system by opportunistic pathogens represents a common cause of consultation. Neurocysticercosis illustrates a parallel epidemic to that of AIDS. Epidemiological phenomenon suggests mutual protection between both infections. See paper

Virology cover.jpg

Featured cover article in Virology Shared antigenic epitopes on the V3 loop of HIV-1 gp120 and proteins on activated human T cells. Shown for the first time that our CD4 T-cells are killed by the immune system due to molecular mimicry. See paper

Shared antigenic epitopes on the V3 loop of HIV-1 gp120 and proteins on activated human T cells. Trujillo JR, Rogers RA, Brain JD. Virology. 1998;246(1):53-62. doi:10.1006/viro.1998.9185

High levels of anti-HIV-1 envelope antibodies in cerebrospinal fluid as compared to serum from patients with AIDS dementia complex. Trujillo JR, Navia BA, Worth J, et al. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12(1):19-25. doi:10.1097/00042560-199605010-00003

Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1. Trujillo JR, Wang WK, Lee TH, Essex M. Virology. 1996;217(2):613-617. doi:10.1006/viro.1996.0158

Molecular Mimicry and HIV.jpg

Molecular mimicry Immunologically cross-reactive proteins in the human brain that resemble the V3 loop of HIV GP120 have been identified. An immune response to the V3 loop that generates cross-reactive antibodies to cellular proteins may be an autoimmune mechanism by which HIV can damage the central nervous system. See paper

 

Neurologic manifestations of AIDS: a comparative study of two populations from Mexico and the United States. Trujillo JR, Garcìa-Ramos G, Novak IS, Rivera VM, Huerta E, Essex M. J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8(1):23-29.

Evaluation of Autoantibodies to brain proteins in patients with AIDS Dementia Complex. Trujillo JR, Navia B, McLane MF, Worth J, Lee TH, Essex M. J AIDS, 1994, 7:103-108

Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins. Trujillo JR, McLane MF, Lee TH, Essex M. J Virol. 1993;67(12):7711-7715. doi:10.1128/JVI.67.12.7711-7715.1993

Model_of_HIV-1_Neurotropism.jpg

Neuropathogenesis of HIV-1 Infection Microglia infection by HIV has been pathologically associated with “HIV encephalitis”. Neurons and astrocytes infection by HIV has been associated with “HIV encephalopathy”. The HIV T tropic phenotype is responsible for astrocyte/neuron infection in absence of CD4 receptor and some cases the presence of CXCR4. See paper

Assessment of nutritional status, nutrient intake, and nutrition support in AIDS patients. Trujillo EB, Borlase BC, Bell SJ, Guenther KJ, Swails W, Queen PM, Trujillo JR. J Am Diet Assoc. 1992;92(4):477-478.

Evaluation of autoantibodies to brain proteins in patients with AIDS dementia complex. Trujillo JR, Navia B, McLane MF, Worth JL, Lee TH, Essex M. J Acquir Immune Defic Syndr (1988). 1994;7(2):103-108.